Search results for "Aβ deposition"

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A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds

2021

Background: A wide range of techniques has been developed over the past decades to characterize amyloid-β (Aβ) pathology in mice. Until now, no method has been established to quantify spatial changes in Aβ plaque deposition due to targeted delivery of substances using ALZET® pumps. Objective: Development of a methodology to quantify the local distribution of Aβ plaques after intracerebral infusion of compounds. Methods: We have developed a toolbox to quantify Aβ plaques in relation to intracerebral injection channels using Zeiss AxioVision® and Microsoft Excel® software. For the proof of concept, intracerebral stereotactic surgery was performed in 50-day-old APP-transgenic mice injected wit…

Intracerebral injectionAmyloid βMice TransgenicPlaque Amyloidamyloid-βtransgenic miceStereotaxic TechniqueshistologyMiceAlzheimer DiseaseAnimalsHumansDistribution (pharmacology)implantable infusion pumpdistributional activityAmyloid beta-PeptidesChemistryGeneral NeuroscienceBrainGeneral MedicineImmunohistochemistryplaquesAβ depositionquantificationDisease Models AnimalPsychiatry and Mental healthClinical PsychologyGeriatrics and GerontologyAlzheimer’s diseaseResearch ArticleBiomedical engineeringJournal of Alzheimer's Disease
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P3–200: Relationship between neurofibrillary pathology and Aβ deposition in Alzheimer disease

2006

Pathologymedicine.medical_specialtyEpidemiologybusiness.industryHealth Policymedicine.diseaseAβ depositionPsychiatry and Mental healthCellular and Molecular NeuroscienceDevelopmental NeurosciencemedicineNeurology (clinical)Geriatrics and GerontologyAlzheimer's diseasebusinessAlzheimer's & Dementia
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